Parkinson’s disease is neurodegenerative disease characterized by the loss of dopaminergic neurons in the substantia nigra resulting in a range of motor deficits. There is uncertainty in how MRI metrics relate to disease pathology, especially in regard to cellular changes, iron, and the presence of neuromelanin. This work aims to analyzing MRI parametrics on ex vivo PD midbrains to determine how image contrast, relaxation, and susceptibility changes are related to cellularity and integrity in this brain region. Changes in MRI parametrics were found in the substantia nigra of PD subjects in relation to histological markers.
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