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Abstract #0964

Structural and functional organization of the brain connectome in patients with different motor neuron diseases: a multicenter study

Camilla Cividini1, Federica Agosta1, Silvia Basaia1, Francesca Trojsi2, Nilo Riva3, Cinzia Femiano2, Cristina Moglia4, Edoardo G. Spinelli1, Maria Rosaria Monsurrò2, Yuri Falzone3, Andrea Falini5, Giancarlo Comi3, Adriano Chiò4, Gioacchino Tedeschi2, and Massimo Filippi1,3

1Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 2Department of Medical, Surgical, Neurological, Metabolic and Aging Sciences, University of Campania "Luigi Vanvitelli", Naples, Italy, 3Department of Neurology, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy, 4ALS Center, ‘Rita Levi Montalcini’ Department of Neuroscience, University of Torino, Torino, Italy, 5Department of Neuroradiology and CERMAC, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy

We investigated structural and functional brain network topology in amyotrophic (ALS), primary lateral sclerosis (PLS) and progressive muscular atrophy (PMA) patients and in healthy controls (HC), using graph analysis and connectomics. ALS and PLS patients showed widespread microstructural alterations in sensorimotor network, basal ganglia area and prefrontal cortex and posterior brain regions compared to HC, while PMA subjects did not show significant brain damages. All groups had a relatively preserved global and local functional connectome properties compared to each other. Graph analysis and connectomics might represent a powerful approach to understand the pathophysiological process associated with motor neuron diseases.

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Abstract