Aberrant default mode network (DMN) activity has been related to aging and various neuropsychiatric illnesses. To better understand the neural mechanisms underlying the DMN deactivation, we investigated the triple-relationship among the task-induced deactivation, regional excitation-inhibition balance, and the interregional functional connectivity strength associated with the DMN. Using mediation analysis, we found that the network interaction between DMN and the salience network partially mediated the association between the regional excitation-inhibition balance and the DMN deactivation. This finding bridges DMN-deactivation related findings from various neuroimaging modalities and may provide new insights into the neural mechanisms of the DMN deactivation.
This abstract and the presentation materials are available to members only; a login is required.