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Abstract #0851

Association between tumor acidity and hypervascularity within human gliomas using pH-weighted amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and dynamic susceptibility contrast (DSC) perfusion MRI at 3T

Yulin Wang1, Jingwen Yao2,3,4, Ararat Chakhoyan2,4, Catalina Raymond2,4, Noriko Salamon4, Linda Liau5,6, Phioanh Nghiemphu7, Albert Lai6,7, Whitney Pope4, Timothy Cloughesy7, and Benjamin Ellingson2,3,4,6,8,9

1Department of Radiology, People’s Liberation Army General Hospital, Beijing, China, 2Brain Tumor Imaging Laboratory (BTIL), Center of Computer Vision and Imaging Biomarker, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 3Department of Bioengineering, Henry Samueli School of Engineering and Applied Science, University of California, Los Angeles, Los Angeles, CA, United States, 4Department of Radiological Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 5Department of Neurosurgery, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 6UCLA Brain Research Institute (BRI), David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 7Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 8Physics and Biology in Medicine, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States, 9Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, United States

In the current study, we employed a fast pH-weighted molecular MRI technique using amine chemical exchange saturation transfer echoplanar imaging (CEST-EPI) and compared to dynamic susceptibility contrast (DSC) perfusion MRI, in order to examine the association between tumor acidity and vascularity in 82 patients with histologically confirmed gliomas. We observed colocalized regions of altered vascularity and acidity in tumors within individual patients, and significant positive correlation between median magnetization transfer ratio asymmetry (MTRasym) at 3ppm and relative cerebral blood volume (rCBV) within T2 hyperintense lesions. But areas of contrast enhancement were more complex and did not show a strong, predictable relationship.

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