Abstract #0850

An Extracorporeal Circulation Mouse Model for Simultaneous Measurements of Dynamic Contrast-Enhanced Arterial Input Functions and Radiotracer Blood Concentrations

Philipp Backhaus^1,2,3, Florian Büther¹, Lydia Wachsmuth³, Lynn Frohwein², Klaus Schäfers², Sven Hermann², Michael Schäfers^1,2, and Cornelius Faber³

¹Department of Nuclear Medicine, University of Münster, Münster, Germany, ²European Institute for Molecular Imaging - EIMI, University of Münster, Münster, Germany, ³Translational Research Imaging Center - TRIC, University of Münster, Münster, Germany

Quantification of the arterial input function (AIF) in small animals is challenging in both dynamic contrast-enhanced (DCE)-MRI and in radiotracer studies. We present a novel extracorporeal circulation mouse model for DCE-measurements of the AIF in mice. The approach allows parallel measurement of tissue contrast dynamics as well as of radiotracer AIF using a β-microprobe integrated into the extracorporeal circulation.

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