Hypertension has been associated with alterations in vascular function and an imbalanced water management of brain tissue, yet the underlying mechanisms for these pathologies remain unclear. To further elucidate possible mechanisms of the fluid homeostasis in the brain, we performed non-invasive MR imaging on normotensive and spontaneous hypertensive rats. We assessed total brain and regional brain volumes, as well as diffusional and water exchange properties of the brain tissue.
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