Abstract #0750

Impaired glymphatic transport and loss of peri-arterial AQP4 expression in spontaneously hypertensive stroke prone rats compared to normotensive WKY controls

sunil koundal¹, Simon Sanggaard¹, Yuechuan Xue¹, Xiaodan Liu¹, Joanna Wardlaw^2,3,4, Maiken Nedergaard^5,6, Hedok Lee ¹, and Helene Benveniste¹

¹Department of Anesthesiology, Yale school of medicine, new haven, CT, United States, ²Center for Clinical Brain Sciences, The University of Edinburgh, Edinburgh, United Kingdom, ³UK Dementia Research Institute, The University of Edinburgh, Edinburgh, United Kingdom, ⁴Row Fogo Centre for Research into Ageing and the Brain, The University of Edinburgh, Edinburgh, United Kingdom, ⁵Center for Translational Neuromedicine, University of Rochester Medical School, Rochester, NY, United States, ⁶Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark

Cerebral small vessel disease (CSVD) is one of the important vascular factor contributing to the cognitive impairment and dementia. Clinically, CSVD hallmarks includes MR white matter hyperintensities and dilated perivascular spaces. Brain-wide perivascular transit passageways for CSF, also known as Glymphatic system has recently been described as cerebral metabolic waste clearance pathway. We evaluated Glymphatic transport by DCE-MRI in middle aged spontaneously hypertensive stroke prone (SHRSP) rats and normal Wistar Kyoto (WKY) rats, which demonstrated significant impairment of Glymphatic transport in brain parenchyma in 7-month old SHRSP rats in comparison to controls.

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