The glymphatic system transports cerebral spinal fluid throughout the brain to clear metabolic and cellular waste during sleep. While there is growing recognition of the critical role this system plays in maintaining normal brain health and in explaining pathology, there are no known noninvasive imaging methods to measure and characterize the efficacy of glymphatic transport in vivo. In this study, we designed, constructed, and tested a glymphatic transport magnetic resonance imaging (MRI) flow phantom. Using it, we determined it may be possible to detect interstitial glymphatic flows via diffusion MRI acquisition methods.
This abstract and the presentation materials are available to members only; a login is required.