Perinatal brain injury, such as perinatal hypoxia from chronic lung disease, results in devastating, neurologic impairment. The immediate and long-term effects on brain energy metabolism of glucose – a major source of energy for the brain - are not known. Previous studies have shown that perinatal brain injury from perinatal hypoxia results in long-term decreases in neuronal oxidative metabolism of glucose and decreased synthesis of N-acetylaspartate. In this study, we utilized dynamic glucoCEST enhancement MRI to investigate the pattern of glucose uptake and metabolism between the mice of normoxic and hypoxic treatment.
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