Abstract #0482

Human Brain 31P NMR Spectra at 7T: UDP-Glucose Assignment Revisited

Jimin Ren^1,2, A Dean Sherry^1,2,3, and Craig R Malloy^1,2,4

¹Advanced Imaging Research Center, UT Southwestern Medical Center, Dallas, TX, United States, ²Department of Radiology, UT Southwestern Medical Center, Dallas, TX, United States, ³Department of Chemistry, University of Texas at Dallas, Richardson, TX, United States, ⁴VA North Texas Health Care System, Dallas, TX, United States

In a typical human brain ³¹P NMR spectrum, a small peak is often present at ~-9.7 ppm, near the α-ATP and NAD+/NADH signals. This ³¹P resonance, accounting for ~1/30th of the brain α-ATP signal, has been considered to be a doublet and assigned to UDPG. Here we present strong evidence to show that the -9.7 ppm signal is in fact a finely structured quartet. This finding has direct impact on current ³¹P NMR method for evaluation of brain redox, which requires UDPG correction. It may also have implication on our interpretation of brain energy metabolism based on ³¹P NMR data.

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