Architectural and morphological changes of hepatocytes (the major parenchymal cells carrying out most of the metabolic functions of the liver) are key diagnostic findings for liver diseases and are associated with important biological events. However, such information can currently only be assessed by liver biopsy. Quantitative temporal diffusion spectroscopy imaging (qTDSI), which uses different modulated gradient waveforms to measure ADC values equivalent to the use of multiple diffusion times (Δ), has been shown to provide accurate, high-resolution maps of cell size in solid tumors. In this study, we demonstrated that qTDSI can map hepatocyte sizes in mice in vivo.
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