Abstract #0042

Brain Microstructural Changes Support Cognitive Deficits in Normal Children Born to HIV-infected Mothers

Santosh Kumar Yadav¹, Rakesh K Gupta², Sabah N Ahmed¹, Sheema Hashem¹, Ajaz A Bhat¹, Ravindra K Garg³, Vimala Venkatesh⁴, Muhammad W Azeem⁵, and Mohammad Haris^1,6

¹Division of Translational Medicine, Sidra Medicine, Doha, Qatar, ²Department of Radiology and Imaging, Fortis Memorial Research Institute, Gurgaon, India, ³Department of Neurology, King George Medical University, Lucknow, India, ⁴Department of Microbiology, King George Medical University, Lucknow, India, ⁵Department of Psychiatry, Sidra Medicine, Doha, Qatar, ⁶Laboratory Animal Research Center, Qatar University, Doha, Qatar

In the current study, we evaluated the brain integrity [by mapping the fractional anisotropy (FA) and mean diffusivity (MD)] and neurocognitive performance (NP) in normal children (NCI) born to HIV-infected mother compared to normal children (NCH) born to healthy mother and HIV-infected children (HI). Reduced FA in multiple brain sites of HI and NCI children suggests loss of tissue integrity while altered MD indicates presence of cerebral edema. Presence of tissue changes and abnormal cognition in absence of HIV-infection in NCI children advice that ART may have detrimental effects on brain.

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