Pulmonary function parameters like the ratio of expiratory volume in one second (FEV1) and forced vital capacity (FVC) are the current gold standard for disease diagnosis and monitoring. However, early disease detection remains limited due to missing regional information. In this study the forced expiratory maneuver was captured with a dynamic MRI acquisition, as used in Fourier decomposition or phase-resolved functional lung imaging (PREFUL), for FEV1/FVC mapping. Results were compared with spirometry, PREFUL and hyperpolarized MRI in four healthy subjects and one patient with cystic fibrosis and suggest a potentially increased sensitivity in comparison with the tidal breathing approach.
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