Abstract #5522

Can ve be larger than one? A modification for asymmetric vascular permeability in Toft’s model may reveal glymphatic dysfunction in tumor

Pei-Lun Yu¹, Ming Cheng¹, Kun-I Chao¹, Cheng-He Li¹, Chi-Shiun Chiang¹, Kung-Chu Ho², Yi-Jui Liu³, Ruey-Hwang Chou⁴, and Fu-Nien Wang¹

¹Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Hsinchu, Taiwan, ²Nuclear Medicine, Chang Gung Memorial Hospital, Linkou, Taiwan, ³Department of Automatic Control Engineering, Feng Chia University, Taichung, Taiwan, ⁴China Medical University Graduate Institute of Cancer Biology, Taichung, Taiwan

The v_e is limited between 0 and 1 by definition. However, we observed large v_e when fitted the Toft’s model or its modified version to both Gd-DTPA and D₂O perfusion MRI. In this study, we modified the v_e to P_as*v_e to incorporate the asymmetry permeability into model. Therefore, the region with high P_as*v_e in D₂O perfusion imaging may be attributed to the blocked pathway of water draining, which could be correlated to glymphatic dysfunction in tumor.

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