Abnormal intraocular fluid flow or clearance is involved with a variety of eye diseases such as diabetic retinopathy, but there is a lack of non-destructive methods to assess the permeability directly of water in the eye. In this study we investigate the feasibility of different MRI sequences for direct imaging of deuterium oxide inflow in the mouse eye. Balanced steady state free precession provided high signal to noise ratio for imaging deuterium oxide in the intraocular fluid, providing dynamic imaging of intraocular water inflow.
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