Abstract #5245

Assessing feasibility and reproducibility of a bundle-specific framework on in vivo axon diameter estimates at 300mT/m

Muhamed Barakovic^1,2, Gabriel Girard¹, David Romascano¹, Jonathan Rafael-Patino¹, Maxime Descoteaux^3,4, Giorgio Innocenti^1,5,6, Derek K. Jones², Jean-Philippe Thiran^1,7, and Alessandro Daducci^1,7,8

¹Signal Processing Laboratory 5 (LTS5), Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, ²Cardiff University Brain Research Imaging Centre (CUBRIC), Cardiff University, Cardiff, United Kingdom, ³Sherbrooke Connectivity Imaging Laboratory (SCIL), University of Sherbrooke, Sherbrooke, QC, Canada, ⁴Sherbrooke Molecular Imaging Center, Department of Nuclear Medicine and Radiobiology, Faculty of Medicine and Health Science, University of Sherbrooke, Sherbrooke, QC, Canada, ⁵Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden, ⁶Brain and Mind Institute, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland, ⁷University Hospital Center (CHUV) and University of Lausanne, Lausanne, Switzerland, ⁸Department of Computer Science, University of Verona, Verona, Italy

In vivo quantitative estimation of axon diameter in the white matter is a potential new tool for studying the structural and functional architecture of the brain. Recently, the feasibility of axon diameter estimation with diffusion-weighted MRI (DW-MRI) has been questioned. In this work, we explore the feasibility of bundle-specific axon diameter mapping in the context of a reproducibility study using the Convex Optimization Modeling for Microstructure informed Tractography (COMMIT) framework. Our results show that DW-MRI axon diameter estimatesof the corpus callosum and of the corticospinal tract are comparable to histological reports in previous studies.

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