Abstract #5137

Deformable registration of calf muscle MRI using an improved Demons approach

Sarath Chintalapati¹, Christopher C Conlin², Gwenael Layec³, Stephen T Decker³, Nan Hu⁴, Jiawei Dong², Christopher Hanrahan², Michelle Mueller⁵, Lillian Khor⁶, Vivian S Lee², and Jeff L Zhang²

¹Electrical and Computer Engineering, University of Utah, Salt Lake City, UT, United States, ²Department of Radiology and Imaging Sciences, University of Utah, Salt Lake City, UT, United States, ³Department of Internal Medicine, Division of Geriatrics, University of Utah, Salt Lake City, UT, United States, ⁴Department of Internal Medicine, Division of Bioinformatics, University of Utah, Salt Lake City, UT, United States, ⁵Department of Internal Medicine, Division of Vascular surgery, University of Utah, Salt Lake City, UT, United States, ⁶Department of Internal Medicine, Division of Cardiology, University of Utah, Salt Lake City, UT, United States

Lower-extremity peripheral arterial disease (PAD) as a major clinical problem and MRI, which measures multiple aspects of the function of the calf muscles, such as muscle perfusion and oxygenation has not been significantly used for this. The reason being no efficient scanning and processing to compare data acquired during the course of treatment. Here we propose to register the calf MRI images using a modified Demons registration method which is more efficient. This method involves first a fast rigid registration and then the Demons deformable registration, by first applying rigid translation and rotation which substantially improved the registration performance for the calf muscle images.

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