1Research Center of Translational Image, Teipei Medical University, Taipei, Taiwan, 2Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 3Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, 4Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan