Abstract #4953

Alteration of Resting-state Functional Networks is Associated with Post Concussion Symptoms in Mild Traumatic Brain Injury

Nai-Chi Chen¹, Chia-Feng Lu^1,2,3, Li-Chun Hsieh^1,4,5, Sho-Jen Cheng^1,5, Yu-Chieh Jill Kao^1,4, Ho-Fang Huang^1,6, and Cheng-Yu Chen^1,4,5

¹Research Center of Translational Imaging, College of Medicine, Taipei Medical University, Taipei, Taiwan, ²Department of Anatomy and Cell Biology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ³Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan, ⁴Department of Radiology, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan, ⁵Department of Medical Imaging, Taipei Medical University Hospital, Taipei, Taiwan, ⁶Department of Medical Research, Taipei Medical University Hospital, Taipei, Taiwan

A subgroup of patients with mild traumatic brain injury (mTBI) suffer from a series of post-concussion symptoms, such as headache, dizziness, and cognitive deficits. These patients also present altered neural connectivity compared to healthy controls (HC). In our study, we examined resting-state functional connectivity in 30 mTBI patients and 35 HC using independent component analysis. We found that patients showed lower functional connectivity in several resting-state networks, and the left frontoparietal network was associated with the level of dizziness in patients. We concluded that the alterations of resting-state neural networks may support post-concussion symptoms after mTBI.

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