Abstract #4861

Volumetric Amide Proton Transfer-Weighted (APTw) Image Metrics as Biomarkers for the Identification of Tumor Progression in Patients with Post-treatment Glioblastoma

Shanshan Jiang^1,2, Hye-Young Heo¹, Yi Zhang^1,3, and Jinyuan Zhou¹

¹Johns Hopkins University, Baltimore, MD, United States, ²Zhujiang Hospital, Southern Medical University, Guangzhou, China, ³Center for Brain Imaging Science and Technology, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China

We quantified the accuracy of volumetric APTw image derived metrics in identifying recurrent malignant glioma. 31 patients with suspected recurrent glioblastoma underwent a volumetric APTw imaging sequence at 3T. Volumes with Gd-enhancing, FLAIR abnormality and APTw hyperintensity were drawn as regions of interest (ROIs). Ratios and APTw histogram parameters of volumetric ROIs were calculated and analyzed. There were significant differences in multiple parameters between treatment effects and recurrent tumor. APT/Gd and Gd-APT_10%showed the highest diagnostic performance. FLAIR-Mean showed reasonable diagnostic performance with great operation simplicity.

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