Abstract #4860

Advanced MRI and MRS precursors to progression in Grade II and III Glioma

Tracy L Luks¹, Yan Li¹, Marisa LaFontaine¹, Angela Jakary¹, Michael Wahl², Susan M Chang³, and Sarah J. Nelson¹

¹Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, United States, ²Radiation Oncology, University of California San Francisco, San Francisco, CA, United States, ³Neurological Surgery, University of California San Francisco, San Francisco, CA, United States

The goal of this project is to identify serial advanced imaging markers that reveal tumor progression in grade II and III gliomas prior to the Response Assessment in Neuro-Oncology Criteria (RANO) criteria for progression. Serial advanced imaging demonstrated significant changes associated with tumor activity prior to the clinical determination of tumor progression. In diffusion imaging, there were declines in nFA, and an increase in nADC in the contrast enhancing lesions. In spectroscopic imaging, there were declines in nNAA and nCRE, and increases in nCho, nLIP and nLAC.

This abstract and the presentation materials are available to members only; a login is required.

Join Here