Abstract #4831

Proximal Internal Carotid Artery Stenosis Associates with Diffuse Wall Thickening in Petrous Arterial Segment of Moyamoya Disease Patients: A 3D MR Vessel Wall Imaging Study

Xiaoyi Chen^1,2, Jian Wang³, Bing Zhang⁴, Dongye Li^1,2, Huiyu Qiao², Shuai Liu², Yongjun Han¹, Hualu Han², Yongbo Yang³, Fei Zhou⁴, Xueping Li⁴, and Xihai Zhao²

¹Center for Brain Disorders Research, Capital Medical University, Beijing, China, ²Center for Biomedical Imaging Research, Tsinghua University, Beijing, China, ³Department of Neurosurgery, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China, ⁴Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China

It has been shown that rapid reduction of lumen diameter at the proximal ICA can be seen in moyamoya disease (MMD) patients. The arterial wall thickness at downstream of proximal ICA may aggravate cerebral ischemia and affect the outcome of revascularization. This study sought to investigate the association between proximal ICA stenosis and diffuse wall thickening in ipsilateral petrous ICA in MMD patients. We found that proximal ICA stenosis was significantly associated with wall thickness (r = 0.434, p<0.001) and presence of diffuse wall thickening (odds ratio=4.433, 95% confidence interval 1.980–9.925, p<0.001) in ipsilateral petrous ICA in MMD patients.

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