Compared with participants with COMT rs4680-GG, the healthy Han Chinese participants with rs4680-A-allele showed higher degree centrality and functional connectivity in medial prefrontal cortex in resting-state BOLD. The rs4680-A-allele carriers also performed better in 3-back performance than rs4680-GG carriers, and the accuracy of 3-back has significant correlation with functional connectivity value, which indicated that the COMT rs4680 mutation modulated the functional connectivity and working memory performance.
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