Abstract #4637

Optimization of breath hold cerebrovascular reactivity mapping (BH CVR) at ultra-high field through temporal correction of the hemodynamic response function

Shruti Agarwal¹, Jun Hua^2,3, Haris I. Sair¹, Sachin K. Gujar¹, Hanzhang Lu^2,3, and Jay J. Pillai^1,4

¹Division of Neuroradiology, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ²Division of MR Research, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States, ³F. M. Kirby Research Center For Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, MD, United States, ⁴Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Cerebrovascular reactivity (CVR) provides clinical insight into vascular health and is useful for identifying cortical regions affected by neurovascular uncoupling (NVU). BOLD imaging using breath-hold (BH) tasks can be effectively used for CVR mapping. At 7T, spatial specificity can be improved relative to standard 3T imaging, but optimization of CVR maps is often problematic. We propose temporal correction of the theoretical hemodynamic response function (HRF) to account for subject-wise temporal adjustment of the average respiration-induced hemodynamic response to a BH task to optimize 7T BH CVR maps in cases of poor patient task compliance.

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