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Abstract #4559

Assessment of the effect of maternal posture on the placental oxygenation transport by means of BOLD MRI

Esra Abaci Turk1, Jie Luo1,2, Natalie Copeland1, Michelle Restrepo1, Ata Turk3, Borjan Gagoski1, Lawrence L. Wald4,5,6, Elfar Adalsteinsson6,7,8, Drucilla J. Roberts9, Polina Golland7,10, P. Ellen Grant1, and William H. Barth Jr11

1Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children's Hospital, Boston, MA, United States, 2School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China, 3Electrical Computer Engineering Department, Boston University, Boston, MA, United States, 4Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, United States, 5Radiology, Harvard Medical School, Boston, MA, United States, 6Harvard-MIT Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 7Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 8Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, United States, 9Pathology, Massachusetts General Hospital, Boston, MA, United States, 10Computer Science and Artificial Intelligence Laboratory (CSAIL), Massachusetts Institute of Technology, Cambridge, MA, United States, 11Maternal-Fetal Medicine, Obstetrics and Gynecology, Massachusetts General Hospital, Boston, MA, United States

Aorta-caval compression due to maternal posture can change uterine artery blood flow, which is the major determinant of maternal intervillous perfusion and may affect MRI measures of placental oxygenation. We investigated the effect of maternal posture on estimates obtained from BOLD MRI of the placenta. We observed higher oxygenation signals in the supine position for a group at younger gestational age. In the group with higher gestational age, the influence of the maternal position on oxygen transport was inconsistent. These findings underscore the need to account for the effect of maternal posture on MRI studies of utero-placental circulation.

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