Abstract #4558

Estimating global cerebral venous oxygenation in the human fetus using QSM

Brijesh Kumar Yadav^1,2, Sagar Buch³, Uday Krishnamurthy^1,2, Pavan Jella², Edgar Hernandez-Andrade⁴, Anabela Trifan², Lami Yeo⁴, Sonia Hassan⁴, E. Mark Haacke^1,2, Roberto Romero^4,5, and Jaladhar Neelavalli^2,6

¹Department of Biomedical Engineering, Wayne State University, Detroit, MI, United States, ²Department of Radiology, Wayne State University, Detroit, MI, United States, ³The MRI Institute for Biomedical Research, Waterloo, ON, Canada, ⁴Department of Obstetrics and Gynecology, Wayne State University, Detroit, MI, United States, ⁵Perinatology Research Branch, NICHD/NIH/DHHS, Detroit, MI, United States, ⁶Philips Innovation Campus, Philips India Limited, Banglore, India

Unobstructed oxygen supply is important for proper health and development of the growing fetus and therefore, fetal cerebral oxygenation measurement has been attempted previously using SWI. However, vessel curvature and oblique fetal orientation posed a major challenge in the oxygenation measurement, especially in younger foetuses. To overcome these problems, we present the first application of quantitative susceptibility mapping for the fetal brain oxymetry. We also studied the effect of resolution on QSM using simulations. Results showed the mean putative fetal cerebral oxygenation was 67%±7% and minimum of 5 voxels around the vessel and 5 slices gives <3% error in oxygenation.

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