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Abstract #4534

The Relationship between Glutamate and BOLD signal changes During Face-Name Paired-Associates Encoding and Retrieval Task in Healthy Adults - A combined 1H-MRS and fMRI study

H Zhang1, PW Chiu1,2, SWH Wong3, T Liu 4, GHY Wong4, Q Chan5, and HKF Mak1,2,6

1Department of Diagnostic Radiology, The University of Hong Kong, Hong Kong, Hong Kong, 2State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, Hong Kong, 3Department of Educational Psychology, Chinese University of Hong Kong, Hong Kong, Hong Kong, 4Department of Social Work and Administration, The University of Hong Kong, Hong Kong, Hong Kong, 5Philips Healthcare, Hong Kong, Hong Kong, 6Alzheimer’s Disease Research Network, The University of Hong Kong, Hong Kong, Hong Kong

Glutamate is hypothesized to be the neurotransmitter in mediating BOLD fMRI. In our study, face-name paired-associates (FN-PA) encoding and retrieval tasks are used to investigate the relationship between glutamate and the BOLD signal changes in 72 healthy adults of varying age. Our results showed that [Glx]abs in the left hippocampus to be significantly positively correlated with the activations in the memory-related circuitry obtained from the FN-PA encoding and retrieval tasks. This might implicate the role of glutamate as the neurotransmitter mediating the BOLD signal changes in the memory tasks.

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