Abstract #4533

On the (non-)equivalency of monopolar and bipolar settings for deep brain stimulation fMRI studies of Parkinson’s disease patients

Ileana Hancu¹, Radhika Madhavan², Alexandre Boutet³, Manish Ranjan³, Julia Prusik⁴, Davix Xu³, Suneil Kalia³, Mojgan Hodaie³, Walter Kucharczyk³, Jeffrey Ashe¹, Alfonso Fasano³, Julie Pilitsis⁴, and Andres Lozano³

¹GE Global Research Center, Niskayuna, NY, United States, ²GE Global Research Center, Bangalore, India, ³University Hospital Network, Toronto, ON, Canada, ⁴Albany Medical Center, Albany, NY, United States

The equivalency of brain responses in fMRI studies of Parkinson’s disease (PD) patients studied in monopolar and bipolar deep brain stimulation (DBS) configurations was assessed. Five PD patients underwent 30s/30s ON/OFF DBS fMRI scans using their clinical (monopolar) settings and an equivalent bipolar setting, in which the cathode remained unchanged, and a proximal electrode was rendered positive; the voltage was increased by 30% to compensate for the reduced efficacy of the bipolar setting. Monopolar and bipolar configurations resulted in different patterns of brain activation; blind monopolar-bipolar conversion should be avoided for purposes of understanding mechanisms of DBS action.

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