Abstract #4363

Pulmonary Ventilation Imaging in Cystic Fibrosis Using Oxygen-enhanced MRI: Comparison with Hyperpolarized Helium-3 MRI

Wei Zha¹, Robert V Cadman¹, Scott K Nagle^1,2,3, and Sean B Fain^1,2,4

¹Medical Physics, University of Wisconsin-Madison, Madison, WI, United States, ²Radiology, University of Wisconsin-Madison, Madison, WI, United States, ³Pediatrics, University of Wisconsin-Madison, Madison, WI, United States, ⁴Biomedical Engineering, University of Wisconsin-Madison, Madison, WI, United States

Recent technical advances in oxygen-enhanced (OE) MRI using 3D radial UTE sequence support quantitative differentiation of diseased vs healthy lungs using ventilation defect percent (VDP). A cohort of cystic fibrosis (CF) subjects with different disease severities underwent spirometry, hyperpolarized (HP) 3He and OE-MRI and a subset of those returned for a repeat visit 1-2 weeks later. The results suggest global VDP measures from HP- and OE-MRI were correlated (ρ=0.80, p<0.0001) with comparable test-retest repeatability, showed similar correlation with spirometry. Moreover, UTE OE-MRI with isotropic spatial resolution provides both structural and functional evaluations of obstructed lungs.

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