A widespread, minimally-invasive method for early detection of lung cancer is urgently needed in the lung cancer clinic. Using high resolution magic angle spinning magnetic resonance spectroscopy, we measured paired tissue and serum samples from the same patients. We correlated serum and tissue results to discover and verify serum markers for lung cancer types and stages and predicted overall survival for early Stage I lung cancer. Measured from serum, prolonged survival is associated with relative overexpression of glutamine, valine, glycine, and relative suppression of glucose and lipids.
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