It is a challenge to differentiate non-enhanced solid tumor from edema in glioblastoma. This study applied the restricted diffusion model to high b-value diffusion weighted images to characterize glioblastoma. The formation of the restricted diffusion model was derived for bi-polar diffusion gradients. The parameters fitted by the restricted diffusion model can differentiate solid tumor from edema and normal-appearing white matter and grey matter, better than the conventional apparent diffusion coefficient and the bi-exponential model without accounting for diffusion restriction of intra-cellular water.
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