Abstract #3816

Anisotropy of Anomalous Diffusion Helps in Grading of Gliomas

Boyan Xu¹, Lu Su², Zhenxiong Wang³, Yang Fan⁴, Bing Wu⁴, Gaolang Gong⁵, Wenzhen Zhu³, Peiyi Gao², and Jia-Hong Gao¹

¹Center for MRI Research, Peking University, Beijing, China, ²Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China, ³Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China, ⁴MR Research China, GE Healthcare, Beijing, China, ⁵State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

Anomalous diffusion model has been introduced and shown to be beneficial in clinical applications, compared with conventional diffusion models. However, the anisotropy of anomalous diffusion was neglected and its clinical feasibility remains uncertain. In this study, the use of anisotropy of anomalous diffusion is investigated for differentiating low- and high-grade cerebral gliomas. Based on the results, it is shown that the anisotropy of anomalous diffusion offers advantages compared to that of conventional diffusion models, indicating its potential to facilitate future studies of neuropathological changes in clinical populations.

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