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Abstract #3772

Cortical Cerebral Blood Flow in Aging: Effects of Haematocrit, Sex and Ethnicity.

Lorna A. Smith1, Andrew Melbourne2, David Owen2, M. Jorge Cardoso2, Carole H. Sudre2, Therese Tillin1, Magdalena Sokolska3, David Atkinson4, Nish Chaturvedi1, Sebastien Ourselin2, Alun D. Hughes1, Frederik Barkhof5,6,7, and H. R. Jager8

1Dept. of Population Science and Experimental Medicine, Institute of Cardiovascular Sciences, University College London, London, United Kingdom, 2Translational Imaging Group, Dept. of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, 3Dept. of Medical Physics and Biomedical Engineering, University College Hospital, London, United Kingdom, 4Centre for Medical Imaging, University College London, London, United Kingdom, 5Inst. of Neurology, University College London, London, United Kingdom, 6Inst. of Healthcare Engineering, University College London, London, United Kingdom, 7Dept. of Radiology and Nuclear Medicine, VU University Medical Centre, Amsterdam, Netherlands, 8Neuroradiological Academic Unit, Dept. of Brain Repair and Rehabilitation, University College London, London, United Kingdom

Cerebral blood flow (CBF) estimates using arterial spin labelling (ASL) show unexplained variability in older populations. We studied the impact of haematocrit (Hct) on CBF quantification in a tri-ethnic elderly population cohort. Hct was measured from blood samples and pseudo-continuous ASL performed on 3T MR. CBF was estimated using a fixed value of 43.5% (model 1) and individually measured Hct (model 2) to calculate the longitudinal relaxation time of blood in simplified Buxton equations. CBF estimates using individual Hct were lower than CBF estimates using a mean Hct in all ethnic and sex categories except white European men.

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