Abstract #3701

Case Report: Hyperpolarized 13C Metabolic Imaging of a Castration-Resistant Prostate Cancer Patient

Casey Y. Lee^1,2, Benjamin J. Geraghty^1,2, Justin Y. C. Lau^1,2,3, Albert P. Chen⁴, William J. Perks⁵, Masoom A. Haider⁶, Urban Emmenegger^7,8, and Charles H. Cunningham^1,2

¹Medical Biophysics, University of Toronto, Toronto, ON, Canada, ²Physical Sciences, Sunnybrook Research Institute, Toronto, ON, Canada, ³Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom, ⁴GE Healthcare, Toronto, ON, Canada, ⁵Pharmacy, Sunnybrook Research Institute, Toronto, ON, Canada, ⁶Medical Imaging, University of Toronto and Ontario Institute of Cancer Research, Toronto, ON, Canada, ⁷Sunnybrook Odette Cancer Centre and Research Institute, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, ⁸Institute of Medical Science, University of Toronto, Toronto, ON, Canada

The feasibility of applying hyperpolarized ¹³C MRI to acquire metabolic (lactate, pyruvate) images of the vertebral region of a castration-resistant prostate cancer patient was investigated in this pilot study. The lactate and pyruvate signal-to-noise ratios (SNRs) of spine, back muscle, aorta, and kidney are reported. The summary of patient’s clinical history is illustrated to aid the understanding of implications of ¹³C-lactate signals observed in this study.

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