Abstract #3700

Hyperpolarized carbon-13 MRS of liver in a high-fat/high sugar diet guinea pig model

Lauren Smith¹, Lanette Friesen-Waldner¹, Kevin Sinclair¹, Trevor Wade^1,2, Timothy Regnault^3,4,5, and Charles McKenzie^1,2,5

¹Medical Biophysics, Western University, London, ON, Canada, ²Robarts Research Institute, London, ON, Canada, ³Physiology and Pharmacology, Western University, London, ON, Canada, ⁴Obstetrics and Gynaecology, Schulich Medicine & Dentistry, London, ON, Canada, ⁵Maternal, Fetal & Newborn Health, Children's Health Research Institute, London, ON, Canada

Effects of a life long high-fat/high sugar diet (Western diet: WD) upon pyruvate liver metabolism were observed in a group of young adult male guinea pigs (N=26). Proton density fat-fraction images were reconstructed using IDEAL water fat separation. Metabolism data were obtained using dynamic spectroscopy of hyperpolarized carbon-13 enriched pyruvate. Guinea pigs fed a life long WD displayed a significantly higher hepatic fat fraction and a delayed time to peak for the conversion of pyruvate to lactate. These results indicate that life long consumption of a WD in growing animals is associated with markers of dysfunctional hepatic metabolic function.

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