Abstract #3640

The roles of sensorimotor and default mode-memory retrieval networks in staging PD cognitive decline

Meng-Hsiang Chen¹, Weiyan Yin², Wei-Che Lin¹, and Weili Lin³

¹Department of Diagnostic Radiology, Kaohsiung Chang Gung Memorial Hospital, Chang Gung University College of Medicine, Kaohsiung, Taiwan, ²Department of Biomedical Engineering and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States, ³Department of Radiology and Biomedical Research Imaging Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, United States

In addition to motor disability, the development of cognitive decline is one of the most notorious symptoms in Parkinson’s disease (PD). Yet, a biomarker capable of accurately diagnosing cognitive impairments in PD patients remains elusive. Our results, based on resting-state functional MRI, suggested that functional connectivity in sensorimotor together with default mode-memory retrieval networks may serve a promising biomarker either for staging cognitive decline or neuropsychiatric scores.

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