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Abstract #3639

Motor compensation in Parkinson’s disease (PD): a multimodal neuroimaging study

Nicolas Villain1,2, Stéphane Lehéricy2,3, Nadya Pyatigorskaya2,3, Romain Valabrègue2, Sara Fernandez-Vidal2, Rahul Gaurav2, Olivier Jaubert2, Marie-Odile Habert4, Graziella Mangone2,5, Jean-Christophe Corvol1,2,5, Marie Vidailhet1,2, and David Grabli1,2

1Neurology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 2Institut du Cerveau et de la Moelle Epinière, Paris, France, 3Neuroradiology, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 4Nuclear Medicine, Groupe Hospitalier Pitié Salpêtrière, Paris, France, 5Centre d'Investigation de Recherche Clinique, Groupe Hospitalier Pitié Salpêtrière, Paris, France

Motor compensation mechanisms in PD rely on very distinct levels of evidence and have never been assessed altogether. They were tested among 68 early PD patients who underwent dopaminergic imaging and MRI (T1 neuromelanin, fMRI, DTI). We created an adjusted motor severity index (ratio between akinetic motor severity and neuromelanin substantia nigra alteration) and performed correlations between this index and the hypothesized compensation mechanisms. As a result, new dopaminergic synapses or more active dopaminergic synapses, reorganization of motor and cognitive subcortical loops and of the associative areas of the cerebellum are the main motor compensation mechanisms in early PD.

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Abstract