Abstract #3623

CORRELATION OF IMMUNE ACTIVATION BIOMARKERS AND MRS MEASURES IN ACUTE HIV INFECTION

Napapon Sailasuta¹, Michelle L. D’Antoni², Philip Chan³, Thep Chalermchai⁴, Pasiri Sithinamsuwan⁵, Somporn Tipsuk⁴, Suteeraporn Pinyakorn⁵, Bonnie Slike⁴, Shelly Krebs⁴, Vedbar Khadka⁶, Eugene Kroon⁴, Robert Paul⁷, Serena Spudich⁸, Victor Valcour⁹, Jintanat Ananworanich^5,10, and Lishomwa Ndhlovu²

¹Tropical Medicine, University of Hawaii, kapolei, HI, United States, ²Tropical Medicine, University of Hawaii, Honolulu, HI, United States, ³Memory and Aging Center, Department of Neurology, University of California, San Francisco, CA, United States, ⁴SEARCH, The Thai Red Cross AIDS Research Centre, Bangkok, Thailand, ⁵U.S. Military HIV Research Program, Silver Spring, MD, United States, ⁶Office of Biostatistics & Quantitative Health Sciences, University of Hawaii, Honolulu, HI, United States, ⁷Missouri Institute of Mental Health, St. Louis, MO, United States, ⁸Neurology, Yale University, New Haven, CT, United States, ⁹Memory and Aging Center, San Francisco, CA, United States, ¹⁰Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, MD, United States

Proton MRS was performed in 51 acute HIV participants. We observed Inverse correlations between sCD163 and markers of neuronal integrity (BG and PCG NAA) in select brain regions suggests regional variability to neuronal injury in AHI. Further, correlations between CSF sCD163 and BG Cho and mI reveal that membrane turnover activity and glia activation that occur early in infection remain susceptible to CNS neuroinflammation. Our observation suggests select brain injury linked to myeloid activation persists even early ART in AHI arguing for additional interventions to halt detrimental neuroinflammation.

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