Abstract #3569

Combined FDG-PET and hyperpolarized pyruvate-MRSI (hyperPET) for cancer metabolic phenotyping – a pilot study

Sissel Bisgaard¹, Andreas Ettrup Clemmensen¹, Abubakr Eldirdiri², Helle Hjorth Johannesen¹, Jan Henrik Ardenkjær-Larsen², Adam Espe Hansen¹, and Andreas Kjær¹

¹Department of Clinical Physiology, Nuclear Medicine & PET and Cluster for Molecular Imaging, Rigshospitalet and University of Copenhagen, Copenhagen, Denmark, ²Center for Hyperpolarization in Magnetic Resonance, DTU Elektro, Technical University of Denmark, Kgs. Lyngby, Denmark

Molecular imaging of cancer metabolism in vivo is increasingly employed in clinical settings. Both ¹⁸F-FDG PET and hyperpolarized [1-¹³C]pyruvate MRSI are sensitive to glucose metabolism but differ in which part of the glycolytic pathway is probed. We hypothesize that hyperPET may improve cancer specific metabolic phenotyping. Simultaneous ¹⁸F-FDG PET and hyperpolarized [1-¹³C]pyruvate MRSI (hyperPET) was used in a pilot study, examining the metabolic characteristics exhibited by four different cancer cell lines in nude mice. The results indicated that the combined modalities may distinguish between cancer types.

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