Abstract #3296

Imaging the perivascular spaces and lenticulostriate arteries at 3T and 7T to provide insight into the pathophysiology of neurodegenerative and neurovascular diseases

Giuseppe Barisano¹, Samantha J. Ma², Danny JJ. Wang², Yonggang Shi², Arthur Toga², and Meng Law^1,2

¹Radiology, University of Southern California, Los Angeles, CA, United States, ²Stevens Institute of Neuroimaging and Informatics, University of Southern California, Los Angeles, CA, United States

The CSF microcirculation in the brain is not well understood and the role of the perivascular spaces in the clearance of metabolic waste products (including amyloid beta and tau) is still debated. We hypothesize that the increased permeability of the BBB and the resulting passage of blood products into the perivascular spaces may be responsible for the obstruction of CSF-ISF flow. Using a novel T1-weighted 3D Turbo spin-echo with variable flip angles at 3T and 7T, we are able to demonstrate leakage of fibrin from the small lenticulostriate arteries into the perivascular spaces.

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