Abstract #3165

Resting-state fMRI study of brain activation using low-intensity repetitive transcranial magnetic stimulation in rats.

Bhedita J Seewoo^1,2,3, Kirk W Feindel³, Sarah J Etherington², and Jennifer Rodger^1,4

¹Experimental and Regenerative Neurosciences, School of Biological Sciences, The University of Western Australia, Crawley, Australia, ²School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia, ³Centre for Microscopy, Characterisation and Analysis, The University of Western Australia, Nedlands, Australia, ⁴Perron Institute for Neurological and Translational Research, Perth, Australia

Repetitive transcranial magnetic stimulation (rTMS) is a non-invasive neuromodulation technique used to treat many neuropsychiatric conditions. However, the mechanisms underlying its mode of action are still unclear. This is the first rodent study using resting-state fMRI to examine low-intensity (LI) rTMS effects, in an effort to provide a direct means of comparison between rodent and human studies. Our study shows that similar to human rTMS, 10 Hz LI- rTMS alters the resting brain activity of rats directly at the site of stimulation (e.g. cortex) as well as in remote but inter-connected brain regions (e.g. hippocampus).

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