The Locus Coeruleus (LC) and the Substantia Nigra (SN) are located in the mid-brain are known to show severe cell loss in several neurodegenerative diseases (e.g., Alzheimer’s disease). Developing new imaging techniques to quantify the signal changes in these regions is of high clinical relevance. In this pilot study of five healthy adults from different age groups, the LC and SN were evaluated for neuromelanin and iron content with an Magnetisation Transfer-weighted sequence and with Quantitative Susceptibility Mapping, respectively.
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