Abstract #3150

On Resonance Variable Delay Multiple Pulse (onVDMP) CEST MRI for Monitoring Stem Cell Therapy in Experimental Autoimmune Encephalomyelitis

Aline Thomas¹, Jiadi Xu², Shen Li¹, Piotr Walczak¹, Peter Calabresi³, Peter van Zijl², and Jeff Bulte¹

¹Radiology, Johns Hopkins School of Medicine, Baltimore, MD, United States, ²Radiology, Kennedy Krieger Institute, Baltimore, MD, United States, ³Neurology, Johns Hopkins School of Medicine, Baltimore, MD, United States

In mice with experimental autoimmune encephalomyelitis, spatiotemporal signal changes were detected with on resonance variable delay multiple pulse (onVDMP) CEST MRI for the brain and spinal cord. Transplantation of glial-restricted precursor cells resulted in normalization of those signal changes during the pre-onset stage of the disease.

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