Abstract #3087

Regional Brain Changes in Autonomic, Mood, and Cognitive Control Areas in Adolescents with Single Ventricle Heart Disease

Sadhana Singh¹, Bhaswati Roy², Nancy Halnon³, Alan Lewis⁴, Mary Woo², Nancy Pike², and Rajesh Kumar^1,5,6,7

¹Department of Anesthesiology, University of California Los Angeles, Los Angeles, CA, United States, ²UCLA School of Nursing, University of California Los Angeles, Los Angeles, CA, United States, ³Division of Pediatric Cardiology, University of California Los Angeles, Los Angeles, CA, United States, ⁴Division of Pediatric Cardiology, Children’s Hospital Los Angeles, Los Angeles, CA, United States, ⁵Department of Radiological Sciences, University of California Los Angeles, Los Angeles, CA, United States, ⁶Department of Bioengineering, University of California Los Angeles, Los Angeles, CA, United States, ⁷Brain Research Institute, University of California Los Angeles, Los Angeles, CA, United States

Adolescents with single ventricle heart disease (SVHD) show both white and gray matter injury in multiple brain areas that control autonomic, mood, and cognitive functions that are deficient in the condition. However, the nature and extent of brain injury in SVHD are unclear. Using diffusion tensor imaging based MD procedures, we showed wide-spread chronic tissue changes in SVHD subjects in areas involved in autonomic, mood, and cognitive regulatory functions. These findings may have resulted from hypoxia/ischemia- or developmental-induced processes accompanying the condition.

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