Abstract #3085

Hippocampal Subfield-specific Tractography in Epilepsy Patients at 7 Tesla

John W Rutland¹, Rebecca E Feldman¹, Lara V Marcuse², Madeline C Fields², Bradley N Delman³, Prantik Kundu ¹, Patrick R Hof⁴, and Priti Balchandani¹

¹Translational and Molecular Imaging Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ²Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ³Department of Radiology, Icahn School of Medicine at Mount Sinai, New York, NY, United States, ⁴Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States

This is the first investigation to use diffusion tensor imaging at 7 Tesla to quantify changes in the structural connectivity of individual hippocampal subfields in epilepsy patients. Diffusion imaging and automated hippocampal subfield segmentation were performed on 19 epilepsy patients and 10 healthy controls. We found that hippocampal volumes are reduced bilaterally in epilepsy patients compared with controls. Connectivity in the left fimbria and right hippocampal-amygdaloid transition area is significantly reduced in epilepsy patients compared with controls. These findings suggest that connectivity of hippocampal subfields are independently affected in epilepsy patients.

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