Abstract #3055

Simple and fast hyperpolarization of a biomolecule: Theory and Experiment

Stephan Berner^1,2,3, Stephan Knecht^1,4, Andreas Benjamin Schmidt^1,4, Mirko Zimmermann¹, Jürgen Hennig¹, Dominik von Elverfeldt¹, and Jan-Bernd Hövener⁴

¹Department of Radiology, Medical Physics, Medical Center—University of Freiburg, Faculty of Medicine, University of Freiburg, Freiburg, Germany, ²DKTK, Freiburg, Germany, ³DKFZ, Heidelberg, Germany, ⁴Department of Radiology and Neuroradiology, Section Biomedical Imaging, MOIN CC University Medical Center Schleswig-Holstein, University of Kiel, Kiel, Germany

Hyperpolarization overcomes the biggest limitation of MRI: its low sensitivity, and enables metabolite mapping. Hyperpolarized ¹³C magnetization can be produced by transferring the spin order of parahydrogen into ¹³C by hydrogenation followed by a sequence of ¹H and ¹³C pulses. However, it is possible to hyperpolarize AA’X spin systems by two pulses on ¹³C. Theoretical models were developed to describe the polarization transfer and significant signal increase was observed for the biomolecule succinate after spin order transfer directly in the magnet of a commercial MRI system. The experimental data is well described by theoretical calculations except for an overall scaling factor.

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