Metabolic imaging of biologically-relevant hyperpolarized agents allows measurement of metabolic processes in real time in-vivo. We demonstrate dynamic metabolic imaging of a single bolus of co-polarized [2-13C]pyruvate and [1,4-13C2]fumarate in control as well as in rats with liver necrosis. Chemical shift imaging (CSI) of such a mixture is challenging due to the large spectral dispersion of resulting resonances, which could lead to severe chemical shift displacement artifacts if acquired by conventional slice-selective excitation pulses. Here we obtain CSI information by a volumetric method using alternate 3D spectrally-selective excitation of sub-bands containing fewer resonances.
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