Multipotent mesenchymal stem cells (MSCs) can be labeled with superparamagnetic iron-oxide nanoparticles (SPION) particles to track single cells with MRI, and thereby follow MSC infiltration. However, a limitation with conventional MR sequences is that their long echo times are unable to measure fast signal decays, which occur in dense bone tissue and with high SPION infiltration. Ultra-short echo time (UTE) MRI can capture these rapidly decaying signals. In this work, we use 3D cones to track tissue development after injection of SPION labeled MSCs in an ovine model.
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