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Abstract #3033

Smart thermosensitive liposomes for effective solid tumor therapy with MRI tracking at 21.1 T

Jens T. Rosenberg1, Kevin Affram2, Ofonime Udofot2, Mandip Singh2, Sunil Krishnan3, Renee Reams2, and Edward Agyare2

1The National High Magnetic Field Laboratory, Florida State University, Tallahassee, FL, United States, 2College of Pharmacy and Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL, United States, 3University of Texas MD Anderson Cancer Center, Houston, TX, United States

Here we show the ability of using Gadolinium (Gd) labeled thermosensitive liposomal nanoparticle (TSLnp) as a delivery system for anticancer drug, gemcitabine (Gem) to human pancreatic tumors. Pancreatic cancer (PCa) due to its high malignancy, poor prognosis and resistance to chemotherapy is one of the leading cancer-associated death in the United States. The proposed agent showed significant Gem accumulation in heated tumor relative to free Gem. Gd labeled TSLnp (Gd-TSLnp) show contrast in ex vivo tumor tissue. The Gd-TSLnp show increased T1 contrast in vivo with an implanted tumor compared to Gd and targets the tumor tissue.

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Abstract