We developed and compared multiple magnetization transfer (MT) pulse sequence strategies to characterize myocardial fibrosis without the need for gadolinium contrast at 3T. We demonstrated in an initial study of 4 healthy volunteers that a free-breathing, single-shot GRE is the most effective technique for producing high quality myocardial MT ratio maps. We will continue refining and investigating this sequence as a method for quantifying both focal and diffuse fibrosis in patients with heart failure.
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